Physiological sensing by nuclear condensates
We study how pH and related environmental cues alter the physical state of transcriptional and chromatin-regulatory assemblies.
Research
From tissue microenvironment to gene regulation
Tissues are dynamic physicochemical environments. We seek general principles that explain how physiological variables reshape gene-regulatory machinery and guide immune-cell adaptation.
Inflammatory gene regulation and memory
We investigate how environmental states are encoded in chromatin organization, transcriptional dynamics, and lasting inflammatory programs.
Myeloid-cell identity and adaptation
We explore how tissue physiology influences macrophage and monocyte state, differentiation, function, and disease-associated behavior.
People
Meet the lab
Zhongyang Wu, Ph.D.
wuzhongyang@ustc.edu.cnProfessor and Principal Investigator
Zhongyang Wu is a professor and Principal Investigator in the Division of Life Sciences and Medicine， and the State Key Laboratory of Immune Response and Immunotherapy at the University of Science and Technology of China (USTC). He grew up in Jiangxi, China, and earned his B.S. from Nanchang University. He received his Ph.D. from Tsinghua University with Dr. Xiaohua Shen, studing epigenetic regulation in stem cells. He then completed his postdoctoral training with Dr. Xu Zhou at Boston Children’s Hospital and Harvard Medical School, investigating how immune cells sense and respond to environmental pH.
Since 2026, the Wu Lab has sought to understand how the physicochemical properties of tissue microenvironments reshape tissue niches and regulate myeloid-cell development, function, and adaptation through the physical organization of gene-control machinery.
Outside the lab, Zhongyang enjoys calligraphy, cooking, and playing badminton.
Selected publication
Featured work
Regulation of inflammatory responses by pH-dependent transcriptional condensates
Wu Z., Pope S.D., et al. This study identifies transcriptional condensates as intracellular pH sensors that translate tissue acidity into gene-specific inflammatory responses.
News
News & updates
Recruitment
We are building our team
The Wu Laboratory welcomes applications from postdoctoral fellows, Ph.D. students, and master’s students interested in tissue immunology, biomolecular condensates, and immune-cell adaptation.
Join us
Build new biology with us
We welcome inquiries from motivated postdoctoral fellows, Ph.D. students, and master’s students interested in immunology, gene regulation, chromatin biology, and the physical organization of cells. Please email a CV and a brief description of your research interests.
Contact
Find us at USTC
Address
Yisuan Building, West Campus
University of Science and Technology of China
Hefei, Anhui, China